| 9/1/2012 | Tuskegee (10-2) | 6 | vs | Alabama A&M | 7 | Birmingham AL | SIAC (D2) | |
| 9/8/2012 | Alabama A&M | 14 | at | Ark Pine Bluff (10-2,9-1) | 10 | |||
| 9/15/2012 | Prairie View (3-8,3-6) | 30 | at | Alabama A&M | 42 | |||
| 9/22/2012 | Alabama A&M | 42 | at | Texas Southern (2-9,2-7) | 13 | |||
| 9/29/2012 | Grambling (1-10,0-9) | 17 | at | Alabama A&M | 38 | |||
| 10/6/2012 | Alabama A&M | 35 | at | Mississippi Valley State (5-6,5-4) | 0 | |||
| 10/13/2012 | Alcorn State (4-7,4-5) | 21 | at | Alabama A&M | 20 | |||
| 10/27/2012 | Alabama State (7-4,7-2) | 31 | vs | Alabama A&M | 13 | Birmingham AL | ||
| 11/3/2012 | Southern (4-7,3-6) | 23 | at | Alabama A&M | 24 | OT | ||
| 11/10/2012 | Alabama A&M | 21 | at | Jackson State (7-5,7-3) | 35 | |||
| 11/17/2012 | Alabama A&M | 7 | at | Auburn (3-9) | 51 | at SEC |
| vs Alabama A&M | vs Other Opponents | Alabama A&M compared to OOs | |
| Record: | 4-7 | 52-62 | |
| Points Scored: | 21.55 | 23.18 | 1.63 |
| Points Allowed: | 23.91 | 27.19 | -3.28 |
| Margin: | -2.36 | -4.01 | -1.65 |
| Total Points: | 45.46 | 50.37 | -4.91 |