| 8/24/2012 | Jamestown | 19 | vs | Rocky Mountain | 38 | Miles City MT | @ Front | |
| 8/25/2012 | Peru State | 35 | at | Dakota State | 27 | vs HAAC | ||
| Point | 34 | at | Edward Waters | 66 | ||||
| Robert Morris IL | 19 | at | Siena Heights | 26 | 2OT | @ MSFA | ||
| 8/30/2012 | Southern Virginia | 0 | at | Morehead State | 55 | @ Pio (1AA) | ||
| Valley City State | 7 | at | Morningside | 49 | @ GPAC | |||
| 9/1/2012 | Dakota State | 14 | at | Dakota Wesleyan | 40 | @ GPAC | ||
| Concordia-Moorhead | 42 | at | Jamestown | 26 | vs MIA (D3) | |||
| Edward Waters | 28 | at | Lane | 45 | @ SIAC (D2) | |||
| Avila | 37 | at | Lindenwood-Belleville | 43 | vs HAAC | |||
| Menlo | 9 | at | Linfield | 30 | @ NWC (D3) | |||
| Haskell | 13 | at | Presentation | 26 | @ D3Ind (D3) | |||
| Olivet | 0 | at | Robert Morris IL | 42 | vs MIAA (D3) | |||
| Louisiana College | 34 | at | Webber International | 16 | vs ASWC (D3) | |||
| Point | 3 | at | West Georgia | 55 | @ GSC (D2) | |||
| 9/8/2012 | Dakota State | 14 | at | Doane | 35 | @ GPAC | ||
| Morehouse | 38 | vs | Edward Waters | 19 | Waycross GA | vs SIAC (D2) | ||
| Robert Morris IL | 14 | at | Haskell | 0 | ||||
| Webber International | 24 | at | Mississippi College | 31 | @ ASWC (D3) | |||
| Lindenwood-Belleville | 23 | at | Panhandle State | 30 | OT | @ D2Ind (D2) | ||
| Menlo | 41 | at | Pomona-Pitzer | 13 | @ SCIAC (D3) | |||
| North Carolina Wesleyan | 14 | at | Southern Virginia | 24 | vs USASC (D3) | |||
| Jamestown | 0 | at | Wisconsin-Stout | 31 | @ WIAC (D3) | |||
| Mayville State | 13 | at | Valley City State | 38 | ||||
| 9/15/2012 | Ave Maria | 14 | at | Birmingham-Southern | 61 | @ SCAC (D3) | ||
| Valley City State | 41 | at | Dakota State | 31 | ||||
| Southern Virginia | 7 | at | Ferrum | 20 | @ USASC (D3) | |||
| Lindenwood-Belleville | 35 | at | Iowa Wesleyan | 28 | @ None (Unk?) | |||
| Webber International | 10 | at | Jacksonville | 33 | @ Pio (1AA) | |||
| South Dakota Tech | 14 | at | Jamestown | 17 | vs D2Ind (D2) | |||
| Edward Waters | 42 | at | Livingstone | 36 | @ CIAA (D2) | |||
| Occidental | 6 | at | Menlo | 56 | vs SCIAC (D3) | |||
| Millsaps | 54 | at | Point | 28 | vs SCAC (D3) | |||
| St Joseph's | 35 | at | Robert Morris IL | 40 | vs GLV (D2) | |||
| Haskell | 7 | at | Tabor | 56 | @ KCAC | |||
| Mayville State | 44 | at | Trinity Bible | 7 | @ None (Unk?) | |||
| 9/22/2012 | Southern Virginia | 30 | at | Ave Maria | 49 | |||
| Bacone | 77 | at | Haskell | 13 | vs CSFL | |||
| Valley City State | 13 | at | Jamestown | 10 | ||||
| Robert Morris IL | 45 | at | Lindenwood-Belleville | 6 | ||||
| Presentation | 7 | at | Mayville State | 54 | vs D3Ind (D3) | |||
| La Verne | 13 | at | Menlo | 59 | vs SCIAC (D3) | |||
| Dakota State | 12 | at | Northwestern IA | 47 | @ GPAC | |||
| Union KY | 10 | at | Webber International | 7 | vs MSC | |||
| 9/29/2012 | Concordia NE | 28 | at | Dakota State | 7 | vs GPAC | ||
| Southwestern | 38 | at | Haskell | 12 | vs KCAC | |||
| Ave Maria | 21 | at | Huntingdon AL | 42 | @ D3Ind (D3) | |||
| Central Methodist | 20 | at | Lindenwood-Belleville | 23 | vs HAAC | |||
| Jamestown | 21 | at | Mayville State | 20 | ||||
| Faulkner | 65 | at | Point | 17 | vs MSC | |||
| Trinity International | 17 | at | Robert Morris IL | 42 | vs MSFA | |||
| Virginia U-Lynchburg | 19 | at | Southern Virginia | 16 | vs None (Unk?) | |||
| Edward Waters | 10 | at | Valdosta State | 58 | @ GSC (D2) | |||
| South Dakota Tech | 39 | at | Valley City State | 28 | vs D2Ind (D2) | |||
| 10/5/2012 | Southern Virginia | 20 | vs | Apprentice | 14 | Salem VA | @ D3Ind (D3) | |
| 10/6/2012 | Hastings | 55 | at | Dakota State | 19 | vs GPAC | ||
| Lindenwood-Belleville | 60 | at | Haskell | 20 | ||||
| Valley City State | 61 | at | Mayville State | 35 | ||||
| Webber International | 19 | at | Menlo | 14 | ||||
| Concordia MI | 9 | at | Robert Morris IL | 42 | vs MSFA | |||
| Point | 13 | at | Shorter | 35 | @ GSC (D2) | |||
| 10/13/2012 | Southern Virginia | 24 | at | Brevard | 59 | @ SAC (D2) | ||
| Dakota State | 35 | at | Briar Cliff | 28 | @ GPAC | |||
| Webber International | 29 | at | Edward Waters | 30 | ||||
| Valley City State | 16 | at | Gustavus Adolphus | 0 | @ MIA (D3) | |||
| Dickinson State | 8 | at | Jamestown | 7 | vs Front | |||
| Lindenwood-Belleville | 35 | at | Kentucky Wesleyan | 42 | @ GLV (D2) | |||
| Lane | 16 | at | Point | 10 | vs SIAC (D2) | |||
| Ave Maria | 7 | at | Shorter | 37 | @ GSC (D2) | |||
| Haskell | 0 | at | Southwestern Assemblies of God | 41 | @ CSFL | |||
| 10/20/2012 | Robert Morris IL | 21 | at | Ave Maria | 0 | |||
| Lindenwood-Belleville | 14 | at | Culver-Stockton | 21 | @ HAAC | |||
| Dakota State | 7 | at | Dordt | 24 | @ GPAC | |||
| Midland U. | 40 | at | Mayville State | 20 | vs GPAC | |||
| Wesley | 30 | at | Menlo | 13 | vs D3Ind (D3) | |||
| Webber International | 10 | at | Point | 7 | ||||
| Edward Waters | 35 | at | Savannah State | 42 | @ MEAC (1AA) | |||
| Concordia AL | 20 | at | Southern Virginia | 14 | vs None (Unk?) | |||
| Jamestown | 13 | at | Valley City State | 10 | ||||
| 10/27/2012 | Edward Waters | 7 | at | Charleston Southern | 42 | @ BigS (1AA) | ||
| Jamestown | 34 | at | Dakota State | 35 | 2OT | |||
| Valley City State | 27 | at | Lindenwood-Belleville | 0 | ||||
| Menlo | 7 | at | Marian IN | 34 | @ MSFA | |||
| Macalester | 41 | at | Mayville State | 14 | vs D3Ind (D3) | |||
| Apprentice | 14 | at | Point | 48 | vs D3Ind (D3) | |||
| Haskell | 0 | at | Robert Morris IL | 58 | ||||
| Ave Maria | 12 | at | Webber International | 35 | ||||
| 11/3/2012 | Mayville State | 34 | at | Dakota State | 33 | |||
| Ave Maria | 14 | at | Edward Waters | 48 | ||||
| Huntingdon AL | 33 | at | Point | 19 | vs D3Ind (D3) | |||
| Webber International | 6 | at | Southern Virginia | 27 | ||||
| Menlo | 21 | at | St Francis IL | 31 | @ MSFA | |||
| Robert Morris IL | 20 | at | Valley City State | 21 | ||||
| 11/10/2012 | Webber International | 13 | at | Apprentice | 12 | @ D3Ind (D3) | ||
| Point | 27 | at | Ave Maria | 24 | 3OT | |||
| Southern Virginia | 17 | at | Edward Waters | 10 | ||||
| Trinity Bible | 34 | at | Haskell | 39 | vs None (Unk?) | |||
| Mayville State | 13 | at | Jamestown | 53 | ||||
| St Francis IN | 44 | at | Lindenwood-Belleville | 7 | vs MSFA | |||
| Pacific Lutheran | 38 | at | Menlo | 21 | vs NWC (D3) | |||
| St Xavier | 28 | at | Robert Morris IL | 19 | vs MSFA | |||
| 11/17/2012 | Edward Waters | 24 | at | Virginia U-Lynchburg | 21 | @ None (Unk?) |