| 8/28/2010 | St Francis IL Fighting Saints 17 @ Marian IN 37 | † |
| 9/11/2010 | McKendree Bearcats 12 @ Marian IN 45 | † |
| 9/18/2010 | Marian IN 17 @ Grand View Vikings 7 | † |
| 9/25/2010 | St Francis IN Fighting Saints 28 @ Marian IN 25 | † |
| 10/2/2010 | Trinity International Trojans 0 @ Marian IN 28 | † |
| 10/9/2010 | Marian IN 25 @ St Xavier Cougars 56 | † |
| 10/16/2010 | Olivet Nazarene Tigers 16 @ Marian IN 42 | † |
| 10/23/2010 | Marian IN 35 @ Notre Dame OH Falcons 22 | |
| 10/30/2010 | Marian IN 20 @ Taylor Trojans 6 | † |
| 11/6/2010 | Marian IN 29 @ Malone Pioneers 7 | † |
| 11/13/2010 | Walsh Cavaliers 14 @ Marian IN 38 | † |
| 11/20/2010 | Marian IN 35 @ Ottawa Braves 20 | |
| 11/27/2010 | Marian IN 6 @ Carroll MT Saints 38 |