| 9/2/2010 | Fairmont State 27 @ Clarion Golden Eagles 16 | |
| 9/11/2010 | Notre Dame OH Falcons 0 @ Fairmont State 38 | |
| 9/18/2010 | Fairmont State 16 @ Shepherd Rams 19 | † |
| 9/25/2010 | Fairmont State 14 @ Glenville State Pioneers 17 1OT | † |
| 9/30/2010 | West Liberty Hilltoppers 43 @ Fairmont State 23 | † |
| 10/9/2010 | Fairmont State 27 @ Charleston WV Golden Eagles 35 | † |
| 10/16/2010 | Fairmont State 0 @ UNC Pembroke Braves 24 | |
| 10/23/2010 | West Virginia Wesleyan Bobcats 14 @ Fairmont State 45 | † |
| 10/30/2010 | Seton Hill Griffons 29 @ Fairmont State 44 | † |
| 11/6/2010 | Fairmont State 17 @ Concord Mountain Lions 41 | † |
| 11/13/2010 | West Virginia State Yellow Jackets 38 @ Fairmont State 63 | † |