| 9/4/2010 | Panhandle State Aggies 32 @ Southwestern 27 | |
| 9/11/2010 | Southwestern 17 @ Sterling Warriors 28 | † |
| 9/18/2010 | Friends Falcons 20 @ Southwestern 17 | † |
| 9/25/2010 | Southwestern 43 @ St Mary KS Spires 21 | † |
| 10/2/2010 | Ottawa Braves 51 @ Southwestern 0 | † |
| 10/16/2010 | Southwestern 35 @ Bethany KS Terrible Swedes 41 | † |
| 10/23/2010 | McPherson Bulldogs 55 @ Southwestern 21 | † |
| 10/30/2010 | Southwestern 52 @ Bethel KS Threshers 14 | † |
| 11/6/2010 | Southwestern 28 @ Tabor Bluejays 55 | † |
| 11/13/2010 | Kansas Wesleyan Coyotes 72 @ Southwestern 48 | † |