| 9/4/2010 | Missouri Valley 17 @ Baker Wildcats 10 | † |
| 9/11/2010 | Culver-Stockton Wildcats 0 @ Missouri Valley 70 | † |
| 9/18/2010 | Missouri Valley 27 @ Lindenwood Lions 45 | † |
| 9/25/2010 | Benedictine KS Ravens 21 @ Missouri Valley 34 | † |
| 10/2/2010 | Missouri Valley 33 @ Graceland Yellow Jackets 12 | † |
| 10/9/2010 | William Jewell Cardinals 23 @ Missouri Valley 40 | † |
| 10/16/2010 | Missouri Valley 31 @ Evangel Crusaders 17 | † |
| 10/23/2010 | Central Methodist Eagles 0 @ Missouri Valley 33 | † |
| 11/6/2010 | Missouri Valley 7 @ MidAmerica Nazarene Pioneers 37 | † |
| 11/13/2010 | Avila Eagles 7 @ Missouri Valley 42 | † |