| 9/4/2010 | Central Methodist 40 @ Culver-Stockton Wildcats 0 | † |
| 9/11/2010 | Lindenwood Lions 69 @ Central Methodist 7 | † |
| 9/18/2010 | Central Methodist 14 @ Benedictine KS Ravens 38 | † |
| 9/25/2010 | Graceland Yellow Jackets 0 @ Central Methodist 10 | † |
| 10/2/2010 | Central Methodist 3 @ William Jewell Cardinals 13 | † |
| 10/9/2010 | Evangel Crusaders 33 @ Central Methodist 21 | † |
| 10/23/2010 | Central Methodist 0 @ Missouri Valley Vikings 33 | † |
| 10/30/2010 | MidAmerica Nazarene Pioneers 56 @ Central Methodist 28 | † |
| 11/6/2010 | Central Methodist 38 @ Avila Eagles 17 | † |
| 11/13/2010 | Baker Wildcats 34 @ Central Methodist 0 | † |