| 9/4/2010 | North Central Cardinals 41 @ Cornell IA 7 | |
| 9/11/2010 | Cornell IA 20 @ Macalester Scots 24 | |
| 9/18/2010 | Cornell IA 14 @ Wartburg Knights 34 | † |
| 9/25/2010 | Cornell IA 10 @ Dubuque Spartans 28 | † |
| 10/2/2010 | Central IA Dutch 52 @ Cornell IA 0 | † |
| 10/9/2010 | Cornell IA 21 @ Luther Norse 24 | † |
| 10/16/2010 | Buena Vista Beavers 26 @ Cornell IA 14 | † |
| 10/30/2010 | Simpson Storm 21 @ Cornell IA 13 | † |
| 11/6/2010 | Cornell IA 12 @ Loras Duhawks 37 | † |
| 11/13/2010 | Coe Kohawks 47 @ Cornell IA 7 | † |