| 9/4/2010 | Wisconsin-Oshkosh Titans 28 @ Central IA 34 | |
| 9/11/2010 | Central IA 28 @ Augustana IL Vikings 23 | |
| 9/18/2010 | Dubuque Spartans 8 @ Central IA 34 | † |
| 9/25/2010 | Central IA 28 @ Coe Kohawks 37 | † |
| 10/2/2010 | Central IA 52 @ Cornell IA Rams 0 | † |
| 10/9/2010 | Simpson Storm 10 @ Central IA 38 | † |
| 10/16/2010 | Central IA 45 @ Luther Norse 26 | † |
| 10/23/2010 | Loras Duhawks 6 @ Central IA 27 | † |
| 10/30/2010 | Central IA 35 @ Buena Vista Beavers 7 | † |
| 11/6/2010 | Wartburg Knights 20 @ Central IA 17 | † |