| 9/4/2010 | Bloomsburg 14 @ Ashland Eagles 24 | |
| 9/11/2010 | Clarion Golden Eagles 13 @ Bloomsburg 41 | † |
| 9/18/2010 | Indiana PA Crimson Hawks 20 @ Bloomsburg 47 | † |
| 9/25/2010 | Bloomsburg 44 @ Millersville Marauders 7 | † |
| 10/2/2010 | East Stroudsburg Warriors 13 @ Bloomsburg 26 | † |
| 10/9/2010 | Bloomsburg 52 @ Cheyney Wolves 14 | † |
| 10/16/2010 | Bloomsburg 23 @ Shippensburg Red Raiders 3 | † |
| 10/23/2010 | West Chester Golden Rams 21 @ Bloomsburg 45 | † |
| 10/30/2010 | Bloomsburg 36 @ C W Post Pioneers 16 | † |
| 11/6/2010 | Kutztown Golden Bears 35 @ Bloomsburg 61 | † |
| 11/13/2010 | Bloomsburg 41 @ Lock Haven Bald Eagles 17 | † |
| 11/20/2010 | Bloomsburg 28 @ California PA Vulcans 26 | † |
| 11/27/2010 | Bloomsburg 14 @ Mercyhurst Lakers 28 | † |