| 9/4/2010 | Fordham Rams 30 @ Bryant 44 | |
| 9/11/2010 | Saint Anselm Hawks 21 @ Bryant 44 | |
| 9/18/2010 | Merrimack Warriors 29 @ Bryant 46 | |
| 9/25/2010 | Bryant 24 @ Central Conn Blue Devils 41 | † |
| 10/2/2010 | Bryant 21 @ Wagner Seahawks 29 | † |
| 10/9/2010 | Sacred Heart Pioneers 24 @ Bryant 25 | † |
| 10/16/2010 | Bryant 12 @ Monmouth NJ Hawks 21 | † |
| 10/30/2010 | Albany NY Great Danes 7 @ Bryant 24 | † |
| 11/6/2010 | Bryant 48 @ St Francis PA Fighting Saints 20 | † |
| 11/13/2010 | Robert Morris Colonials 21 @ Bryant 27 | † |
| 11/20/2010 | Duquesne Dukes 37 @ Bryant 29 | † |