| 9/11/2010 | Wagner 9 @ Assumption Greyhounds 24 | |
| 9/18/2010 | Cornell Rams 7 @ Wagner 41 | |
| 9/25/2010 | Robert Morris Colonials 30 @ Wagner 9 | † |
| 10/2/2010 | Bryant Bulldogs 21 @ Wagner 29 | † |
| 10/9/2010 | Wagner 22 @ Georgetown Hoyas 16 | |
| 10/16/2010 | Wagner 22 @ St Francis PA Fighting Saints 14 | † |
| 10/23/2010 | Duquesne Dukes 21 @ Wagner 20 | † |
| 10/30/2010 | Wagner 20 @ Central Conn Blue Devils 38 | † |
| 11/6/2010 | Monmouth NJ Hawks 20 @ Wagner 31 | † |
| 11/13/2010 | Wagner 14 @ Albany NY Great Danes 24 | † |
| 11/20/2010 | Wagner 22 @ Sacred Heart Pioneers 38 | † |