| 9/4/2010 | Youngstown State 14 @ Penn State Nittany Lions 44 | |
| 9/11/2010 | Butler Bulldogs 7 @ Youngstown State 31 | |
| 9/18/2010 | Central Conn Blue Devils 24 @ Youngstown State 63 | |
| 9/25/2010 | Southern Illinois Salukis 28 @ Youngstown State 31 | † |
| 10/2/2010 | Youngstown State 25 @ Missouri State Bears 35 | † |
| 10/9/2010 | North Dakota State Bison 34 @ Youngstown State 29 | † |
| 10/16/2010 | Youngstown State 38 @ Western Illinois Leathernecks 40 | † |
| 10/23/2010 | Youngstown State 20 @ South Dakota State Jackrabbits 30 | † |
| 10/30/2010 | Northern Iowa Panthers 34 @ Youngstown State 30 | † |
| 11/6/2010 | Youngstown State 39 @ Illinois State Redbirds 41 | † |
| 11/13/2010 | Indiana State Sycamores 30 @ Youngstown State 24 | † |