| 9/11/2010 | North Dakota State Bison 9 @ Northern Iowa 16 | † |
| 9/18/2010 | Stephen F. Austin Lumberjacks 22 @ Northern Iowa 20 | |
| 9/25/2010 | Northern Iowa 0 @ Iowa State Cyclones 27 | |
| 10/2/2010 | South Dakota State Jackrabbits 14 @ Northern Iowa 24 | † |
| 10/9/2010 | Northern Iowa 38 @ Southern Illinois Salukis 45 | † |
| 10/16/2010 | Northern Iowa 19 @ South Dakota Coyotes 14 | |
| 10/23/2010 | Illinois State Redbirds 14 @ Northern Iowa 42 | † |
| 10/30/2010 | Northern Iowa 34 @ Youngstown State Penguins 30 | † |
| 11/6/2010 | Northern Iowa 30 @ Indiana State Sycamores 20 | † |
| 11/13/2010 | Missouri State Bears 14 @ Northern Iowa 38 | † |
| 11/20/2010 | Northern Iowa 14 @ Western Illinois Leathernecks 30 | † |
| 11/27/2010 | Lehigh Mountain Hawks 14 @ Northern Iowa 7 (FBS Playoffs) |