| 9/5/2010 | Southern 37 vs Delaware State Hornets 27 (Orlando FL) | |
| 9/11/2010 | Arkansas-Monticello Boll Weevils 31 @ Southern 7 | |
| 9/25/2010 | Southern 14 @ Alabama A&M Bulldogs 34 | † |
| 10/2/2010 | Ark Pine Bluff Golden Lions 41 @ Southern 23 | † |
| 10/9/2010 | Mississippi Valley State Delta Devils 20 @ Southern 38 | † |
| 10/16/2010 | Southern 45 @ Jackson State Tigers 49 | † |
| 10/23/2010 | Prairie View Panthers 30 vs Southern 16 (Shreveport LA) | † |
| 10/30/2010 | Southern 20 @ Alcorn State Braves 27 | † |
| 11/6/2010 | Texas Southern Tigers 54 @ Southern 7 | † |
| 11/13/2010 | Alabama State Hornets 21 @ Southern 19 | † |
| 11/27/2010 | Grambling Tigers 38 vs Southern 17 (New Orleans LA) | † |