| 9/4/2010 | Langston Lions 27 @ Alcorn State 50 | |
| 9/18/2010 | Alcorn State 27 @ Mississippi Valley State Delta Devils 9 | † |
| 9/25/2010 | Alabama State Hornets 21 @ Alcorn State 41 | † |
| 10/2/2010 | Alcorn State 16 @ Mississippi State Bulldogs 49 | |
| 10/9/2010 | Texas Southern Tigers 30 @ Alcorn State 20 | † |
| 10/16/2010 | Alcorn State 28 @ Grambling Tigers 38 | † |
| 10/21/2010 | Ark Pine Bluff Golden Lions 39 @ Alcorn State 35 | † |
| 10/30/2010 | Southern Jaquars 20 @ Alcorn State 27 | † |
| 11/6/2010 | Alcorn State 41 @ Alabama A&M Bulldogs 24 | † |
| 11/13/2010 | Alcorn State 27 @ Prairie View Panthers 35 | † |
| 11/20/2010 | Alcorn State 14 @ Jackson State Tigers 27 | † |