| 9/3/2010 | Arizona Wildcats 41 @ Toledo 2 | |
| 9/11/2010 | Toledo 20 @ Ohio Bobcats 13 | † |
| 9/18/2010 | Toledo 37 @ Western Michigan Broncos 24 | † |
| 9/25/2010 | Toledo 31 @ Purdue Boilermakers 20 | |
| 10/2/2010 | Wyoming Cowboys 20 @ Toledo 15 | |
| 10/9/2010 | Toledo 14 @ Boise State Broncos 57 | |
| 10/16/2010 | Kent State Golden Flashes 21 @ Toledo 34 | † |
| 10/23/2010 | Ball State Cardinals 24 @ Toledo 31 | † |
| 10/30/2010 | Toledo 42 @ Eastern Michigan Eagles 7 | † |
| 11/9/2010 | Toledo 30 @ Northern Illinois Huskies 65 | † |
| 11/17/2010 | Bowling Green Falcons 14 @ Toledo 33 | † |
| 11/26/2010 | Central Michigan Chippewas 31 @ Toledo 42 | † |
| 12/26/2010 | Florida Intl Golden Panthers 34 vs Toledo 32 (Detroit - Little Ceasar's Bowl) |