| 9/4/2010 | Bowling Green 27 @ Troy Trojans 30 | |
| 9/11/2010 | Bowling Green 20 @ Tulsa Golden Hurricane 33 | |
| 9/18/2010 | Marshall Thundering Herd 28 @ Bowling Green 44 | |
| 9/25/2010 | Bowling Green 21 @ Michigan Wolverines 65 | |
| 10/2/2010 | Buffalo Bulls 28 @ Bowling Green 26 | † |
| 10/9/2010 | Bowling Green 25 @ Ohio Bobcats 49 | † |
| 10/16/2010 | Bowling Green 27 @ Temple Owls 28 | † |
| 10/23/2010 | Kent State Golden Flashes 30 @ Bowling Green 6 | † |
| 10/30/2010 | Bowling Green 17 @ Central Michigan Chippewas 14 | † |
| 11/10/2010 | Miami-Ohio Redhawks 24 @ Bowling Green 21 | † |
| 11/17/2010 | Bowling Green 14 @ Toledo Rockets 33 | † |
| 11/26/2010 | Western Michigan Broncos 41 @ Bowling Green 7 | † |