| 9/4/2010 | S Carolina St | @ | Georgia Tech | ||||||
| 9/11/2010 | MS Valley St | @ | S Carolina St | ||||||
| 9/18/2010 | S Carolina St | @ | Benedict D2 | ||||||
| 10/2/2010 | S Carolina St | @ | Florida A&M | MEAC | |||||
| 10/9/2010 | Norfolk St | @ | S Carolina St | MEAC | |||||
| 10/16/2010 | Bethune-Cookman | @ | S Carolina St | MEAC | |||||
| 10/23/2010 | Hampton | @ | S Carolina St | MEAC | |||||
| 10/30/2010 | S Carolina St | @ | Delaware St | MEAC | |||||
| 11/6/2010 | Howard | @ | S Carolina St | MEAC | |||||
| 11/13/2010 | S Carolina St | @ | Morgan St | MEAC | |||||
| 11/20/2010 | S Carolina St | @ | NC A&T | MEAC |