| 9/2/2010 | Hampton | @ | Central Michigan | ||||||
| 9/11/2010 | Hampton | @ | Howard | MEAC | |||||
| 9/18/2010 | NC A&T | @ | Hampton | MEAC | |||||
| 10/2/2010 | Hampton | @ | Delaware St | MEAC | |||||
| 10/9/2010 | Hampton | @ | North Carolina Central | ||||||
| 10/16/2010 | Norfolk St | @ | Hampton | MEAC | |||||
| 10/23/2010 | Hampton | @ | S Carolina St | MEAC | |||||
| 10/30/2010 | Old Dominion | @ | Hampton | ||||||
| 11/6/2010 | Bethune-Cookman | @ | Hampton | MEAC | |||||
| 11/13/2010 | Hampton | @ | Florida A&M | MEAC | |||||
| 11/20/2010 | Hampton | @ | Morgan St | MEAC |