| 8/27/2009 | Kentucky Wesleyan 3 @ Indianapolis 31 | |
| 9/3/2009 | Kentucky Wesleyan 10 @ Murray St 66 | |
| 9/19/2009 | Kentucky Wesleyan 25 @ Kentucky St 30 | |
| 9/26/2009 | Kentucky Wesleyan 20 @ Southwest Baptist 50 | |
| 10/3/2009 | Central St 30 @ Kentucky Wesleyan 31 2OT | † |
| 10/10/2009 | Urbana 24 @ Kentucky Wesleyan 16 | |
| 10/17/2009 | Grand View 24 @ Kentucky Wesleyan 12 | |
| 10/24/2009 | Kentucky Wesleyan 7 @ St Joseph's 48 | † |
| 10/31/2009 | Kentucky Wesleyan 7 @ Lake Erie 24 | |
| 11/7/2009 | Kentucky Wesleyan 21 @ Lincoln MO 6 | † |
| 11/14/2009 | Missouri S&T 34 @ Kentucky Wesleyan 14 | † |