| 8/27/2009 | Lake Erie 34 @ Gannon 35 | |
| 9/5/2009 | Fairmont St 24 @ Lake Erie 27 1OT | |
| 9/12/2009 | Lake Erie 28 @ West Liberty St 62 | |
| 9/19/2009 | Lake Erie 31 @ St Joseph's 21 | |
| 9/26/2009 | Lake Erie 29 @ Adrian 28 | |
| 10/3/2009 | Ohio Dominican 52 @ Lake Erie 49 | |
| 10/10/2009 | Lake Erie 36 @ Apprentice 3 | |
| 10/17/2009 | Salisbury 7 @ Lake Erie 28 | |
| 10/24/2009 | Urbana 6 @ Lake Erie 20 | † |
| 10/31/2009 | Kentucky Wesleyan 7 @ Lake Erie 24 | |
| 11/7/2009 | Lake Erie 13 @ Wesley 28 |