| 9/5/2009 | Northwestern St | 7 | @ | Houston | 55 | ||||
| 9/12/2009 | Houston | 45 | @ | Oklahoma St | 35 | ||||
| 9/26/2009 | Texas Tech | 28 | @ | Houston | 29 | ||||
| 10/3/2009 | Houston | 41 | @ | UTEP | 58 | CUSA | |||
| 10/10/2009 | Houston | 31 | @ | Mississippi St | 24 | ||||
| 10/17/2009 | Houston | 44 | @ | Tulane | 16 | CUSA | |||
| 10/24/2009 | SMU | 15 | @ | Houston | 38 | CUSA | |||
| 10/31/2009 | Southern Miss | 43 | @ | Houston | 50 | CUSA | |||
| 11/7/2009 | Houston | 46 | @ | Tulsa | 45 | CUSA | |||
| 11/14/2009 | Houston | 32 | @ | UCF | 37 | CUSA | |||
| 11/21/2009 | Memphis | 14 | @ | Houston | 55 | CUSA | |||
| 11/28/2009 | Rice | 14 | @ | Houston | 73 | CUSA | |||
| 12/5/2009 | Houston | 32 | @ | East Carolina | 38 | CUSA | CUSA CG | ||
| 12/31/2009 | Houston | 20 | vs | Air Force | 47 | Armed Forces Bowl |