| 9/5/2009 | Appalachian St | 24 | @ | East Carolina | 29 | ||||
| 9/12/2009 | East Carolina | 20 | @ | West Virginia | 35 | ||||
| 9/19/2009 | East Carolina | 17 | @ | North Carolina | 31 | ||||
| 9/26/2009 | UCF | 14 | @ | East Carolina | 19 | CUSA | |||
| 10/3/2009 | East Carolina | 21 | @ | Marshall | 17 | CUSA | |||
| 10/10/2009 | East Carolina | 21 | @ | SMU | 28 | CUSA | |||
| 10/17/2009 | Rice | 13 | @ | East Carolina | 49 | CUSA | |||
| 10/27/2009 | East Carolina | 38 | @ | Memphis | 19 | CUSA | |||
| 11/5/2009 | Virginia Tech | 16 | @ | East Carolina | 3 | ||||
| 11/15/2009 | East Carolina | 44 | @ | Tulsa | 17 | CUSA | |||
| 11/21/2009 | UAB | 21 | @ | East Carolina | 37 | CUSA | |||
| 11/28/2009 | Southern Miss | 20 | @ | East Carolina | 25 | CUSA | |||
| 12/5/2009 | Houston | 32 | @ | East Carolina | 38 | CUSA | CUSA CG | ||
| 1/2/2010 | Arkansas | 20 | vs | East Carolina | 17 | OT | Liberty Bowl |