| 9/6/2008 | San Diego St | 13 | @ | Notre Dame | 21 | ||
| 9/13/2008 | Michigan | 17 | @ | Notre Dame | 35 | ||
| 9/20/2008 | Notre Dame | 7 | @ | #21 Michigan St | 23 | ||
| 9/27/2008 | Purdue | 21 | @ | Notre Dame | 38 | ||
| 10/4/2008 | Stanford | 21 | @ | Notre Dame | 28 | ||
| 10/11/2008 | Notre Dame | 24 | @ | North Carolina | 29 | ||
| 10/25/2008 | Notre Dame | 33 | @ | Washington | 7 | ||
| 11/1/2008 | #20 Pittsburgh | 36 | @ | Notre Dame | 33 | 4 OT | |
| 11/8/2008 | Notre Dame | 0 | @ | #23 Boston College | 17 | ||
| 11/15/2008 | Notre Dame | 27 | vs | Navy | 21 | Baltimore MD | |
| 11/22/2008 | Syracuse | 24 | @ | Notre Dame | 23 | ||
| 11/29/2008 | Notre Dame | 3 | @ | #5 Southern California | 38 | ||
| 12/24/2008 | Hawaii | 21 | vs | Notre Dame | 49 | Hawaii (Honolulu) |