| 8/31/2006 | Toledo | 43 | @ | Iowa State | 45 | 3 OT | |||
| 9/9/2006 | UNLV | 10 | @ | Iowa State | 16 | ||||
| 9/16/2006 | Iowa State | 17 | @ | Iowa | 27 | ||||
| 9/23/2006 | Iowa State | 14 | @ | #16 Texas | 37 | B12 | |||
| 9/30/2006 | Northern Iowa | 27 | @ | Iowa State | 28 | ||||
| 10/7/2006 | #22 Nebraska | 28 | @ | Iowa State | 14 | B12 | |||
| 10/14/2006 | Iowa State | 9 | @ | #7 Oklahoma | 34 | B12 | |||
| 10/21/2006 | Texas Tech | 42 | @ | Iowa State | 26 | B12 | |||
| 10/28/2006 | Iowa State | 10 | @ | Kansas St | 31 | B12 | |||
| 11/4/2006 | Kansas | 41 | @ | Iowa State | 10 | B12 | |||
| 11/11/2006 | Iowa State | 16 | @ | Colorado | 33 | B12 | |||
| 11/18/2006 | Missouri | 16 | @ | Iowa State | 21 | B12 |