| 9/1/2005 | Southern Illinois | 58 | @ | SE Missouri St | 23 | ||||
| 9/10/2005 | Union KY | 7 | @ | Southern Illinois | 82 | ||||
| 9/17/2005 | Southern Illinois | 28 | @ | Western Michigan | 34 | ||||
| 10/1/2005 | Missouri State | 23 | @ | Southern Illinois | 30 | OT | GW | ||
| 10/8/2005 | Southern Illinois | 34 | @ | Western Illinois | 24 | GW | |||
| 10/15/2005 | Illinois St | 61 | @ | Southern Illinois | 35 | GW | |||
| 10/22/2005 | Southern Illinois | 42 | @ | Indiana St | 20 | GW | |||
| 10/27/2005 | Southern Illinois | 31 | @ | Western Kentucky | 20 | GW | |||
| 11/5/2005 | Youngstown St | 17 | @ | Southern Illinois | 31 | GW | |||
| 11/12/2005 | Southern Illinois | 24 | @ | Northern Iowa | 25 | GW | |||
| 11/19/2005 | N Dakota St | 0 | @ | Southern Illinois | 9 |