| 9/3/2005 | Baylor | 28 | @ | SMU | 23 | ||||
| 9/10/2005 | #14 TCU | 10 | @ | SMU | 21 | ||||
| 9/17/2005 | SMU | 8 | @ | Texas A&M | 66 | ||||
| 9/24/2005 | Tulane | 31 | @ | SMU | 10 | CUSA | |||
| 10/1/2005 | SMU | 13 | @ | Marshall | 16 | OT | CUSA | ||
| 10/8/2005 | SMU | 28 | @ | UAB | 27 | CUSA | |||
| 10/15/2005 | East Carolina | 24 | @ | SMU | 17 | CUSA | |||
| 10/22/2005 | SMU | 13 | @ | Tulsa | 20 | CUSA | |||
| 11/5/2005 | Rice | 7 | @ | SMU | 27 | CUSA | |||
| 11/19/2005 | SMU | 29 | @ | Houston | 24 | CUSA | |||
| 11/26/2005 | UTEP | 27 | @ | SMU | 40 | CUSA |