| 9/3/2005 | #5 Notre Dame | 42 | @ | Pittsburgh | 21 | ||
| 9/10/2005 | #5 Notre Dame | 17 | @ | #20 Michigan | 10 | ||
| 9/17/2005 | Michigan St | 44 | @ | #5 Notre Dame | 41 | OT | |
| 9/24/2005 | #5 Notre Dame | 36 | @ | Washington | 17 | ||
| 10/1/2005 | #5 Notre Dame | 49 | @ | Purdue | 28 | ||
| 10/15/2005 | #1 Southern California | 34 | @ | #5 Notre Dame | 31 | ||
| 10/22/2005 | BYU | 23 | @ | #5 Notre Dame | 49 | ||
| 11/5/2005 | Tennessee | 21 | @ | #5 Notre Dame | 41 | ||
| 11/12/2005 | Navy | 21 | @ | #5 Notre Dame | 42 | ||
| 11/19/2005 | Syracuse | 10 | @ | #5 Notre Dame | 34 | ||
| 11/26/2005 | #5 Notre Dame | 38 | @ | Stanford | 31 | ||
| 1/2/2006 | #4 Ohio State | 34 | vs | #5 Notre Dame | 20 | Fiesta |