| 9/3/2005 | #1 Southern California | 63 | @ | Hawaii | 17 | ||||
| 9/17/2005 | Arkansas | 17 | @ | #1 Southern California | 70 | ||||
| 9/24/2005 | #1 Southern California | 45 | @ | #5 Oregon | 13 | P10 | |||
| 10/1/2005 | #1 Southern California | 38 | @ | Arizona St | 14 | P10 | |||
| 10/8/2005 | Arizona | 21 | @ | #1 Southern California | 42 | P10 | |||
| 10/15/2005 | #1 Southern California | 34 | @ | #5 Notre Dame | 31 | ||||
| 10/22/2005 | #1 Southern California | 51 | @ | Washington | 24 | P10 | |||
| 10/29/2005 | Washington St | 13 | @ | #1 Southern California | 55 | P10 | |||
| 11/5/2005 | Stanford | 21 | @ | #1 Southern California | 51 | P10 | |||
| 11/12/2005 | #1 Southern California | 35 | @ | California | 10 | P10 | |||
| 11/19/2005 | Fresno St | 42 | @ | #1 Southern California | 50 | ||||
| 12/3/2005 | #17 UCLA | 19 | @ | #1 Southern California | 66 | P10 | |||
| 1/4/2006 | #2 Texas | 41 | vs | #1 Southern California | 38 | Rose (BCS) |