| 8/30/2025 | Defiance | at | Rio Grande | MSFA | ||||
| 9/6/2025 | Georgetown KY | at | Rio Grande | MSC | ||||
| 9/20/2025 | Rio Grande | at | Ferris State | at GLIAC | ||||
| 10/4/2025 | Kentucky Christian | at | Rio Grande | |||||
| 10/11/2025 | Rio Grande | at | Pikeville | |||||
| 10/18/2025 | Union KY | at | Rio Grande | |||||
| 10/25/2025 | Rio Grande | at | Point | |||||
| 11/1/2025 | Reinhardt | at | Rio Grande | |||||
| 11/8/2025 | Rio Grande | at | Bluefield VA |