| 8/30/2025 | Pikeville | at | Georgetown KY | at MSC | ||||
| 9/13/2025 | Pikeville | at | Campbellsville | at MSC | ||||
| 9/20/2025 | Cumberland TN | at | Pikeville | MSC | ||||
| 9/27/2025 | Pikeville | at | Maryville | at SAA | ||||
| 10/11/2025 | Rio Grande | at | Pikeville | |||||
| 10/18/2025 | Point | at | Pikeville | |||||
| 10/25/2025 | Pikeville | at | Bluefield VA | |||||
| 11/1/2025 | Union KY | at | Pikeville | |||||
| 11/8/2025 | Kentucky Christian | at | Pikeville | |||||
| 11/15/2025 | Pikeville | at | Reinhardt |