| 9/6/2025 | Greensboro | at | Guilford | USASC | ||||
| 9/13/2025 | Guilford | at | Methodist | at USASC | ||||
| 9/20/2025 | Guilford | at | Washington and Lee | |||||
| 9/27/2025 | Hampden-Sydney | at | Guilford | |||||
| 10/4/2025 | Guilford | at | Gallaudet | |||||
| 10/11/2025 | Shenandoah | at | Guilford | |||||
| 10/18/2025 | Randolph-Macon | at | Guilford | |||||
| 11/1/2025 | Guilford | at | Roanoke | |||||
| 11/8/2025 | Averett | at | Guilford | |||||
| 11/15/2025 | Guilford | at | Bridgewater VA |