| 8/30/2025 | Defiance | at | Rio Grande | at App | ||||
| 9/6/2025 | Judson | at | Defiance | |||||
| 9/13/2025 | Defiance | at | Marian IN | |||||
| 9/27/2025 | Defiance | at | St Francis IN | |||||
| 10/4/2025 | St Xavier | at | Defiance | |||||
| 10/11/2025 | Defiance | at | Olivet Nazarene | |||||
| 10/18/2025 | Taylor | at | Defiance | |||||
| 10/25/2025 | Defiance | at | Indiana Wesleyan | |||||
| 11/1/2025 | Siena Heights | at | Defiance | |||||
| 11/8/2025 | Madonna | at | Defiance | |||||
| 11/15/2025 | Defiance | at | Lawrence Tech |