| 8/31/2025 | Winston-Salem State | vs | Tuskegee | Montgomery AL | vs SIAC | |||
| 9/6/2025 | Winston-Salem State | at | Mars Hill | at SAC | ||||
| 9/13/2025 | Lincoln PA | at | Winston-Salem State | |||||
| 9/20/2025 | Virginia State | at | Winston-Salem State | |||||
| 9/27/2025 | Winston-Salem State | at | Bowie State | |||||
| 10/4/2025 | Virginia Union | at | Winston-Salem State | |||||
| 10/11/2025 | Winston-Salem State | at | Shaw | |||||
| 10/18/2025 | Livingstone | at | Winston-Salem State | |||||
| 10/25/2025 | Winston-Salem State | at | Johnson C Smith | |||||
| 11/8/2025 | Winston-Salem State | at | Fayetteville State |