| 8/30/2025 | West Virginia Wesleyan | at | Post | at NE10 | ||||
| 9/4/2025 | Clarion | at | West Virginia Wesleyan | PSAC | ||||
| 9/11/2025 | Ohio Dominican | at | West Virginia Wesleyan | GMAC | ||||
| 9/20/2025 | West Virginia State | at | West Virginia Wesleyan | |||||
| 9/27/2025 | Frostburg State | at | West Virginia Wesleyan | |||||
| 10/4/2025 | West Virginia Wesleyan | at | Wheeling | |||||
| 10/11/2025 | West Virginia Wesleyan | at | Fairmont State | |||||
| 10/18/2025 | West Liberty | at | West Virginia Wesleyan | |||||
| 10/25/2025 | West Virginia Wesleyan | at | Concord | |||||
| 11/1/2025 | West Virginia Wesleyan | at | Charleston WV | |||||
| 11/15/2025 | Glenville State | at | West Virginia Wesleyan |