| 8/30/2025 | Midwestern State | at | Missouri Southern | LSC | ||||
| 9/6/2025 | Missouri Southern | at | Southwest Baptist | at GLV | ||||
| 9/20/2025 | Northwest Missouri State | at | Missouri Southern | |||||
| 9/27/2025 | Missouri Southern | at | Central Missouri | |||||
| 10/4/2025 | Fort Hays State | at | Missouri Southern | |||||
| 10/11/2025 | Missouri Southern | at | Emporia State | |||||
| 10/18/2025 | Nebraska-Kearney | at | Missouri Southern | |||||
| 10/25/2025 | Missouri Western | at | Missouri Southern | |||||
| 11/1/2025 | Missouri Southern | at | Pittsburg State | |||||
| 11/8/2025 | Missouri Southern | at | Central Oklahoma | |||||
| 11/15/2025 | Washburn | at | Missouri Southern |