| 8/23/2025 | Southern | vs | North Carolina Central | Atlanta GA | vs MEAC | |||
| 8/30/2025 | Southern | at | Mississippi Valley State | |||||
| 9/6/2025 | Alabama State | at | Southern | |||||
| 9/13/2025 | Southern | at | Fresno State | at MW | ||||
| 9/27/2025 | Jackson State | at | Southern | |||||
| 10/11/2025 | Southern | at | Bethune-Cookman | |||||
| 10/18/2025 | Prairie View | at | Southern | |||||
| 10/25/2025 | Florida A&M | at | Southern | |||||
| 11/1/2025 | Southern | at | Ark Pine Bluff | |||||
| 11/8/2025 | Southern | at | Alcorn State | |||||
| 11/15/2025 | Texas Southern | at | Southern | |||||
| 11/29/2025 | Grambling | vs | Southern | New Orleans LA |