| 8/30/2025 | South Dakota | at | Iowa State | at B12 | ||||
| 9/6/2025 | South Dakota | at | Lamar | at SLC | ||||
| 9/13/2025 | Northern Colorado | at | South Dakota | BSky | ||||
| 9/20/2025 | Drake | at | South Dakota | Pio | ||||
| 9/27/2025 | South Dakota | at | North Dakota State | |||||
| 10/4/2025 | Murray State | at | South Dakota | |||||
| 10/11/2025 | South Dakota | at | Indiana State | |||||
| 10/18/2025 | South Dakota | at | Northern Iowa | |||||
| 10/25/2025 | Illinois State | at | South Dakota | |||||
| 11/1/2025 | North Dakota | at | South Dakota | |||||
| 11/8/2025 | South Dakota State | at | South Dakota | |||||
| 11/15/2025 | South Dakota | at | Southern Illinois |