| 8/30/2025 | Wofford | at | South Carolina State | SoCon | ||||
| 9/6/2025 | South Carolina State | at | South Carolina | at SEC | ||||
| 9/13/2025 | Bethune-Cookman | at | South Carolina State | SWAC | ||||
| 9/20/2025 | South Carolina State | at | South Florida | at AAC | ||||
| 9/27/2025 | South Carolina State | at | Charleston Southern | at BigS | ||||
| 10/4/2025 | Savannah State | at | South Carolina State | SIAC (D2) | ||||
| 10/11/2025 | South Carolina State | at | North Carolina A&T | at CAAF | ||||
| 10/25/2025 | South Carolina State | at | Norfolk State | |||||
| 11/1/2025 | Morgan State | at | South Carolina State | |||||
| 11/8/2025 | Howard | at | South Carolina State | |||||
| 11/15/2025 | South Carolina State | at | North Carolina Central | |||||
| 11/22/2025 | South Carolina State | at | Delaware State |