| 8/30/2025 | SE Missouri State | at | Arkansas State | at SBC | ||||
| 9/6/2025 | North Alabama | at | SE Missouri State | UAC | ||||
| 9/13/2025 | SE Missouri State | at | North Dakota State | at MVC | ||||
| 9/20/2025 | Southern Illinois | at | SE Missouri State | MVC | ||||
| 9/27/2025 | SE Missouri State | at | Tennessee-Martin | |||||
| 10/11/2025 | Tennessee State | at | SE Missouri State | |||||
| 10/18/2025 | Eastern Illinois | at | SE Missouri State | |||||
| 10/25/2025 | SE Missouri State | at | Tennessee Tech | |||||
| 11/1/2025 | Charleston Southern | at | SE Missouri State | |||||
| 11/8/2025 | SE Missouri State | at | Gardner-Webb | |||||
| 11/15/2025 | SE Missouri State | at | Western Illinois | |||||
| 11/22/2025 | Lindenwood | at | SE Missouri State |