| 8/28/2025 | West Georgia | at | Samford | UAC | ||||
| 9/6/2025 | The Citadel | at | Samford | |||||
| 9/13/2025 | Samford | at | Baylor | at B12 | ||||
| 9/20/2025 | Samford | at | Western Carolina | |||||
| 9/27/2025 | Furman | at | Samford | |||||
| 10/4/2025 | Samford | at | Mercer | |||||
| 10/18/2025 | Samford | at | VMI | |||||
| 10/25/2025 | Chattanooga | at | Samford | |||||
| 11/1/2025 | Samford | at | Wofford | |||||
| 11/8/2025 | East Tennessee St | at | Samford | |||||
| 11/15/2025 | Samford | at | Austin Peay | at UAC | ||||
| 11/22/2025 | Samford | at | Texas A&M | at SEC |