| 8/28/2025 | Alcorn State | at | Northwestern State | SWAC | ||||
| 9/6/2025 | Northwestern State | at | Minnesota | at B10 | ||||
| 9/13/2025 | Northwestern State | at | Cincinnati | at B12 | ||||
| 9/20/2025 | Northwestern State | at | Prairie View | at SWAC | ||||
| 10/4/2025 | East Texas A&M | at | Northwestern State | |||||
| 10/11/2025 | Northwestern State | at | Houston Christian | |||||
| 10/18/2025 | Northwestern State | at | Southeastern Louisiana | |||||
| 10/25/2025 | Lamar | at | Northwestern State | |||||
| 11/1/2025 | Northwestern State | at | McNeese State | |||||
| 11/8/2025 | Incarnate Word | at | Northwestern State | |||||
| 11/15/2025 | Northwestern State | at | Nicholls State | |||||
| 11/20/2025 | Stephen F. Austin | at | Northwestern State |