| 8/23/2025 | Incarnate Word | at | Nicholls State | |||||
| 8/30/2025 | Nicholls State | at | Troy | at SBC | ||||
| 9/6/2025 | West Georgia | at | Nicholls State | UAC | ||||
| 9/20/2025 | Nicholls State | at | Texas State | at SBC | ||||
| 9/27/2025 | Nicholls State | at | Eastern Kentucky | at UAC | ||||
| 10/4/2025 | Nicholls State | at | Lamar | |||||
| 10/18/2025 | Nicholls State | at | Stephen F. Austin | |||||
| 10/25/2025 | McNeese State | at | Nicholls State | |||||
| 11/1/2025 | Houston Christian | at | Nicholls State | |||||
| 11/8/2025 | Nicholls State | at | Texas-Rio Grande Valley | |||||
| 11/15/2025 | Northwestern State | at | Nicholls State | |||||
| 11/20/2025 | Nicholls State | at | Southeastern Louisiana |