| 8/30/2025 | Southern | at | Mississippi Valley State | |||||
| 9/6/2025 | Mississippi Valley State | at | Tarleton State | at UAC | ||||
| 9/13/2025 | Mississippi Valley State | at | Southeastern Louisiana | at SLC | ||||
| 9/27/2025 | Texas Southern | at | Mississippi Valley State | |||||
| 10/4/2025 | Mississippi Valley State | vs | Florida A&M | Atlanta GA | ||||
| 10/11/2025 | Mississippi Valley State | at | Alabama A&M | |||||
| 10/18/2025 | Lincoln CA | at | Mississippi Valley State | None (Unk?) | ||||
| 10/25/2025 | Mississippi Valley State | at | Alcorn State | |||||
| 11/1/2025 | Mississippi Valley State | at | Bethune-Cookman | |||||
| 11/8/2025 | Jackson State | at | Mississippi Valley State | |||||
| 11/15/2025 | Mississippi Valley State | vs | Alabama State | Mobile AL | ||||
| 11/22/2025 | Mississippi Valley State | at | Prairie View |