| 8/30/2025 | Langston | vs | Grambling | Shreveport LA | Soon (NAIA) | |||
| 9/6/2025 | Grambling | at | Ohio State | at B10 | ||||
| 9/13/2025 | Kentucky State | at | Grambling | SIAC (D2) | ||||
| 9/20/2025 | East Texas A&M | at | Grambling | SLC | ||||
| 9/27/2025 | Grambling | vs | Prairie View | Dallas TX | ||||
| 10/11/2025 | Texas Southern | at | Grambling | |||||
| 10/18/2025 | Grambling | at | Ark Pine Bluff | |||||
| 10/25/2025 | Jackson State | vs | Grambling | Las Vegas NV | ||||
| 11/1/2025 | Alabama A&M | at | Grambling | |||||
| 11/8/2025 | Bethune-Cookman | at | Grambling | |||||
| 11/15/2025 | Grambling | at | Alcorn State | |||||
| 11/29/2025 | Grambling | vs | Southern | New Orleans LA |