| 8/30/2025 | Murray State | at | East Tennessee St | MVC | ||||
| 9/6/2025 | East Tennessee St | at | Tennessee | at SEC | ||||
| 9/13/2025 | East Tennessee St | at | West Georgia | at UAC | ||||
| 9/20/2025 | Elon | at | East Tennessee St | CAAF | ||||
| 9/27/2025 | Mercer | at | East Tennessee St | |||||
| 10/4/2025 | East Tennessee St | at | Furman | |||||
| 10/11/2025 | VMI | at | East Tennessee St | |||||
| 10/18/2025 | East Tennessee St | at | Chattanooga | |||||
| 10/25/2025 | Wofford | at | East Tennessee St | |||||
| 11/8/2025 | East Tennessee St | at | Samford | |||||
| 11/15/2025 | East Tennessee St | at | Western Carolina | |||||
| 11/22/2025 | The Citadel | at | East Tennessee St |