| 8/30/2025 | Charleston Southern | at | Vanderbilt | at SEC | ||||
| 9/6/2025 | Charleston Southern | at | Coastal Carolina | at SBC | ||||
| 9/13/2025 | Lindenwood | at | Charleston Southern | |||||
| 9/20/2025 | Charleston Southern | at | William & Mary | at CAAF | ||||
| 9/27/2025 | South Carolina State | at | Charleston Southern | MEAC | ||||
| 10/4/2025 | Charleston Southern | at | Gardner-Webb | |||||
| 10/11/2025 | Tennessee Tech | at | Charleston Southern | |||||
| 10/18/2025 | Charleston Southern | at | Western Illinois | |||||
| 10/25/2025 | Eastern Illinois | at | Charleston Southern | |||||
| 11/1/2025 | Charleston Southern | at | SE Missouri State | |||||
| 11/15/2025 | Charleston Southern | at | Tennessee-Martin | |||||
| 11/22/2025 | Tennessee State | at | Charleston Southern |