| 8/30/2025 | Syracuse | vs | Tennessee | Atlanta GA | vs SEC | |||
| 9/6/2025 | Connecticut | at | Syracuse | Ind | ||||
| 9/12/2025 | Colgate | at | Syracuse | Pat (1AA) | ||||
| 9/20/2025 | Syracuse | at | Clemson | |||||
| 9/27/2025 | Duke | at | Syracuse | |||||
| 10/4/2025 | Syracuse | at | SMU | |||||
| 10/18/2025 | Pittsburgh | at | Syracuse | |||||
| 10/25/2025 | Syracuse | at | Georgia Tech | |||||
| 10/31/2025 | North Carolina | at | Syracuse | |||||
| 11/8/2025 | Syracuse | at | Miami-Florida | |||||
| 11/22/2025 | Syracuse | at | Notre Dame | at ND | ||||
| 11/29/2025 | Boston College | at | Syracuse |