| 8/30/2025 | Mississippi State | at | Southern Miss | SEC | ||||
| 9/6/2025 | Jackson State | at | Southern Miss | SWAC (1AA) | ||||
| 9/13/2025 | Appalachian State | at | Southern Miss | |||||
| 9/20/2025 | Southern Miss | at | Louisiana Tech | at CUSA | ||||
| 9/27/2025 | Jacksonville State | at | Southern Miss | CUSA | ||||
| 10/9/2025 | Southern Miss | at | Georgia Southern | |||||
| 10/18/2025 | Southern Miss | at | UL Lafayette | |||||
| 10/25/2025 | UL Monroe | at | Southern Miss | |||||
| 11/8/2025 | Southern Miss | at | Arkansas State | |||||
| 11/15/2025 | Texas State | at | Southern Miss | |||||
| 11/22/2025 | Southern Miss | at | South Alabama | |||||
| 11/29/2025 | Troy | at | Southern Miss |